Database : HANSEN Search on : ANTIGENOS DE BACTERIAS/IMUNOL [Subject descriptor] References found : 134 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19590 Author: Lord, Rosanne; Naish, Caroline; Taylor, Clare; Stanford, Cynthia; Stanford, John L; Chacko, Chinoy JG; Debandu, Vivanathan; Samson, Prabhakar D; Berchmans, John; Surendran, Deeradaylu; Ramu, Gopal; Rees, Richard JW. Title: Skin test studies on close contacts of leprosy patients in India. Source: Int. J. Lep;57(4):801-809, dec. 1989. ^btab, ^bgraf. Abstract: Skin-test studies with a series of tuberculins have been carried out in close contacts of multibacillary (MB) leprosy patients around three leprosy centers in India, and casual contacts of the disease around two centers. The results show that the rate of acquisition of leprosin A positivity is associated with age and the closeness of contact with MB leprosy. At the age of 15 years, the differences between the two types of contact were highly significant (p less than 0.00001). Many responses to leprosin A are directed toward the group iv species-specific, antigens of the leprosy bacillus, and the significance of positivity is discussed in relation to protective immunity from leprosy. The differences from Iran show that positivity to leprosin A is not solely the effect of the degree of contact with the disease, but must also have a genetic or environmental element, the latter being favored. The results from Miraj show that the high levels of tuberculin, scrofulin, and vaccin positivity seen in Fathimanagar, and to a lesser extent in Karigiri, are not a consequence of contact with leprosy. BCG vaccination made little difference to the leprosin A positivity of close contacts of leprosy patients, although it significantly enhanced positivity among casual contacts around Miraj (p less than 0.002). BCG vaccination significantly increased tuberculin positivity in Miraj and Karigri, and in those under 11 years of age in Fathimanagar. It made no difference to the already high level of positivity found in older persons around Fathimanagar. Descriptors: Antígenos de Bactérias/imunol Vacina BCG/imunol Hanseníase/epidemiol Hanseníase/transm Índia/epidemiol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a08.pdf / en Location: Br191.1

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Id: 19588 Author: Mutis, Tuna; Van Schoote, Wim CA; Vries, René RP. Title: A peptidoglycan protein complex purified from M Leprae cell walls contains most or all immunodominat M leprae T-cell antigens. Source: Int. J. Lep;57(4):788-793, dec. 1989. . Abstract: The outcome of an infection with Mycobacterium leprae is correlated with the T-cell-mediated immune response developed against this pathogenic agent. The identification of M. leprae antigens that are recognized by T cells is therefore of great importance. In this paper we present the results of in vitro lymphoproliferation assays in which T-cell reactivity was measured against a peptidoglycan-protein complex (PPC) which was purified from the cell wall of M. leprae. Twelve M. leprae-reactive T-cell clones with different antigen specificities from a tuberculoid (TT) leprosy patient showed proliferative responses, but only when PPC was presented by HLA-DR-matched antigen-presenting cells (APCs). Four of these clones were known to react with the recombinant mycobacterial 65-kDa protein. A tetanus-toxoid-reactive T-cell line from a healthy control was not stimulated by this complex, supporting the idea that the stimulation by PPC was antigen specific. Both PPD-reactive and M. leprae-reactive T-cell lines from healthy individuals were stimulated by PPC. However, when this complex was presented to PPD-reactive T-cell lines derived from two lepromatous (LL) leprosy patients, we did not observe any proliferative responses. From these results we conclude that PPC contains most or all of the antigens which stimulate M. leprae-reactive T cells in association with relevant HLA class II molecules, including the 65-kDa protein or at least some immunogenic parts of it. Descriptors: Antígenos de Bactérias/imunol Parede Celular/fisiol Mycobacterium leprae/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a06.pdf / en Location: Br191.1

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Id: 19587 Author: Mullins, raymond J; Basten, Antony. Title: Effect pf preincubation on the proliferative response to antigen by cells from leprosy patients and healthy controls. Source: Int. J. Lep;57(4):777-787, dec. 1989. ^btab, ^bgraf. Abstract: One of the postulated mechanisms contributing to the selective T-cell hyporesponsiveness in patients with leprosy is receptor blockade, the characteristic feature of which is reversibility following preincubation of cells in vitro. To test this hypothesis, peripheral blood mononuclear cells (PBMC) obtained from 17 leprosy patients and 10 healthy Mantoux-positive and -negative controls were cultured freshly or after a period of preincubation in serum-containing medium, and the proliferative responses to Mycobacterium leprae, BCG, and streptokinase-streptodornase (SKSD) were measured. On the basis of the response to M. leprae, the leprosy patients could be divided into low, intermediate and high responders. Preincubation for 2-16 hr resulted in enhanced proliferation by cells from moderate responders, but not from low or high responders. Although the effect was serum dependent, it was neither antigen specific nor was it confined to cells from leprosy patients. Thus, an increase in response to both the crossreactive and unrelated antigens BCG and SKSD occurred, and the same trend was observed when cells from healthy controls were preincubated in serum-containing medium. Furthermore, cells from different individuals displayed varying responses to different antigens following preincubation, suggesting that the effect of this step was neither confined to isolated individuals nor to particular antigens. The addition of pronase to the preincubation step did not further enhance the response to antigen over and above that obtained with preincubation alone. It was therefore concluded that the enhanced proliferative response to antigen following preincubation was an in vitro phenomenon dependent upon the culture conditions employed, was not specific to leprosy, and was not related to receptor blockade. Descriptors: Antígenos de Bactérias/imunol Fenômenos Fisiológicos Sanguíneos Mycobacterium bovis/imunol Mycobacterium leprae/imunol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a05.pdf / en Location: Br191.1

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Id: 19584 Author: Gelber, Robert H; Li, Futian; Cho, SN; Byrd, Sally; Rajagopalan, K; Brennan, Patrick J. Title: Serum antibodies to defined carbohydrate antigens during the course of treated leprosy. Source: Int. J. Lep;57(4):744-751, dec. 1989. . Abstract: Sequential monitoring of 724 sera for antibodies to a neoantigen based on phenolic glycolipid-I (PGL-I) and native lipoarabinomannan (LAM) in 90 leprosy patients undergoing therapy in San Francisco was conducted. Untreated lepromatous patients frequently (91%) had significant antibodies to both moieties. Antibodies were less frequently found in tuberculoid patients (74% to neoantigen and 37% to LAM). In the first 3 years of treatment, average serum antibodies to both moieties fell significantly. Antibodies to LAM fell during each of the first 4 years of therapy, but decreasing antibody levels to the PGL-I neoantigen did not appear to fall consistently after the third year of treatment. A wide variation in the rate of fall of serum antibodies was noted. Sequential changes in the amounts of serum antibodies to the neoantigen and LAM in general paralleled one another but were at times discrepant. Both in San Francisco and Malaysia, skin-smear negative, long-term treated, lepromatous leprosy patients frequently harbored significant antibodies to both PGL-I and LAM. Descriptors: Anticorpos Antibacterianos/imunol Anticorpos Antibacterianos/fisiol Antígenos de Bactérias/imunol Glicolipídeos/imunol Hanseníase/terap Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a02.pdf / en Location: Br191.1

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Id: 13942 Author: Maeda, Yumi; Gidoh, Masaichi; Ishii, Norihisa; Mukai, Chifumi; Makino, Masahiko Title: Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens ..- Source: s.l; s.n; 2003. 9 p. tab, graf. Abstract: The antigenicity of Mycobacterium leprae (M. leprae)-derived cell membrane fraction was examined using human dendritic cells (DCs). Immature DCs internalized and processed the cell membrane components, and expressed M. leprae-derived antigens (Ags) on their surface. The expression of MHC class II, CD86, and CD83 Ags on DCs and CD40 ligand (L)-associated IL-12 p70 production from DCs were up-regulated by the membrane Ags. Moreover these stimulated DCs induced significantly higher level of interferon-gamma (IFN-gamma) production by autologous CD4(+) and CD8(+) T cells than those pulsed with equivalent doses of live M. leprae or its cytosol fraction. Both subsets of T cells from tuberculoid leprosy patients also produced several fold more IFN-gamma than those from normal individuals. Furthermore, the intracellular perforin production in CD8(+) T cells was up-regulated in an Ag-dose dependent manner. These results suggest that M. leprae membrane Ags might be useful as the vaccinating agents against leprosy. (AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol LINFOCITOS T CD4-POSITIVOS/imunol LIGANTE A CD40/fisiol LINFOCITOS T CD8-POSITIVOS/imunol CELULAS DENDRITICAS/imunol INTERFERON TIPO II/bios INTERLEUCINA-12/bios TRANSFORMACAO LINFOCITICA GLICOPROTEINAS DE MEMBRANA/bios MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09083/s

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Id: 13935 Author: Jayapal, V; Selvibai, G; Mahalakshmi, K; Pushkala; Regunath, K; Subramanian, S Title: Comparative study of anti-PGL-1, anti-35 kDa and anti-lipoarabinomannan assays for serodiagnosis of leprosy ..- Source: s.l; s.n; 2001. 9 p. tab. Abstract: Three antibody assays (anti-PGL-1, anti-35 kDa and anti-LAM) were used to determine the levels of antibodies in the sera of untreated leprosy patients. All the three assays showed higher levels of antibodies in BL/LL patients as compared to I and TT/BT patients, as well as healthy controls. BL/LL patients showed positivity of 100 per cent, 84.2 per cent and 78.9 per cent by anti-PGL-1, anti-35 kDa and anti-LAM assays respectively. All the three assays were negative for leprosy in healthy controls. Anti-PGL-1 assay was positive in 20 per cent of TT/BT patients and 17.9 per cent of I patients. Anti-35 kDa assay was negative in all the TT/BT patients and positive in 7.14 per cent of I patients. Anti-LAM assay was positive in 13.3 per cent of TT/BT patients and in 10.7 per cent of I patients. Hence, while these assays are valuable in diagnosing BL/LL patients, their usefulness in diagnosing I, BT or TT leprosy is limited. (AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol TESTES SOROLOGICOS ANTICORPOS ANTIBACTERIAS/sangue ANTIGENOS DE BACTERIAS/imunol GLICOLIPIDIOS/imunol HANSENIASE/sangue HANSENIASE/clas HANSENIASE/diag HANSENIASE/imunol LIPOPOLISSACARIDIOS/imunol Limits: ESTUDO COMPARATIVO HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09162/s

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Id: 13538 Author: Massalski, W; Kozminska-Kubarska, A; Shukla, Rama Raksha Title: Skin reactions to selected antigens in patients with leprosy ..- Source: s.l; s.n; 1982. 4 p. tab. Abstract: The purpose of the work was comparison of reactivity of patients with the lepromatous and the tuberculoid type of leprosy. To 15 patients with the lepromatous and to 20 patients the tuberculoid type several antigens were administered intradermally. The antigens were obtained from alcohol - and acidfast microorganisms isolated from:- skin changes of cases lepromatous type, - skin of a case with tuberculoid type, - skin of a healthy person.The reactions to standard lepromin served as a reference. No correlation was found between the clinical picture, bacteriological examination and reactions to standard lepromin. A high percentage of positive results, observed in the group of cases with lepromatous type, using the antigen prepared from a patient with tuberculoid leprosy is of particular interest. This phenomenon may depend on differences within HLA subgroups in patients with the lepromatous and the tuberculoid type of leprosy. (AU). Descriptors: HANSENIASE/imunol ANTIGENOS DE BACTERIAS/imunol TESTES CUTÂNEOS Limits: HUMANO MASCULINO FEMININO Location: BR191.1; 08985/s

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Id: 13497 Author: Ivanyi, J; Sinha, S; Aston, R; Cussell, D; Keen, M; Sengupta, U Title: Definition of species specific and cross-reactive antigenic determinants of Mycobacterium leprae using monoclonal antibodies ..- Source: s.l; s.n; jun. 1983. 9 p. ilus, tab. Abstract: Four soluble antigens of Mycobacterium leprae have been identified using 12 murine monoclonal antibodies. Their specificity, taxonomic distribution and molecular nature were analysed by radioimmunoassays and by immunoblotting from polyacrylamide electrophoresis gels. A protein antigen MY1 (12K) reacted with one antibody (ML06) without demonstrable cross-reactivity for any of the other 20 tested species of mycobacteria. Another four antibodies which identified antigen MY2 revealed only a marginal degree of cross-reactivity with three other species of mycobacteria. Two antigens shared by several other mycobacteria species were: MY3 represented by five protein bands (35-70K) and a subtilisin resistant molecule MY4 (40-50K) with two distinct determinants and presumably of polysaccharide nature. The described monoclonal antibodies may represent novel valuable diagnostic reagents as well as tools for the purification of antigens which could be explored towards prophylactic or therapeutic immunization against leprosy.(AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM/imunol ELETROFORESE EM GEL DE POLIACRILAMIDA EPITOPOS/anal EPITOPOS/imunol LIGACAO COMPETITIVA ANTIGENOS DE BACTERIAS/anal ANTIGENOS DE BACTERIAS/imunol ANTICORPOS MONOCLONAIS/imunol Limits: SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01394/s

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Id: 13431 Author: Melsom, R; Duncan, M. E; Harboe, M; Bjune, G Title: Antibodies against Mycobacterium leprae antigen 7 from birth to 18 months of age: an indicator of intra-uterine infection in leprosy ..- Source: s.l; s.n; oct. 1980. 7 p. tab, graf. Abstract: All babies of three non-leprosy mothers and ten tuberculoid leprosy mothers and four of five babies of mothers with inactive lepromatous leprosy showed a decline in serum concentration of antibodies against M. leprae antigen 7 during the first 4 months of life, as expected from catabolism of maternal IgG. By contrast, ten of twenty babies of mothers with active lepromatous leprosy showed a decline in concentration of anti-M. leprae 7 antibodies considerably less than expected. This indicates that these babies have been stimulated by M. leprae antigen 7, either as free antigen or by viable M. leprae before birth, and thus that leprosy may occur as a congenital infection. Studies of anti-M. leprae antibodies in repeated serum samples obtained during the first 18 months of life indicated that children of mothers with bacilliferous leprosy are frequently exposed to M. leprae to a sufficient extent to stimulate the immune system of the baby to production of anti-M. leprae antibodies during this period. The consequences of this exposure to M. leprae should be ascertained by careful clinical studies.(AU). Descriptors: HANSENIASE/imunol TROCA MATERNO-FETAL MYCOBACTERIUM LEPRAE/imunol IMUNOGLOBULINA G/metab ENVELHECIMENTO SANGUE FETAL/imunol ANTIGENOS DE BACTERIAS/imunol ANTICORPOS ANTIBACTERIAS/anal Limits: HUMANO FEMININO GRAVIDEZ RECÉM-NASCIDO LACTENTE SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00461/s

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Id: 13429 Author: Nogueira, N; Kaplan, G; Levy, E; Sarno, E. N; Kushner, P; Granelli-Piperno, A; Vieira, L; Colomer Gould, V; Levis, W; Steinman, R Title: Defective gamma interferon production in leprosy ..- Source: s.l; s.n; December 01, 1983. 6 p. tab. Abstract: Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. In contrast, cells from six tuberculoid and borderline tuberculoid patients (TT and BT) produced considerable levels of gamma-IFN under the same experimental conditions. Normal controls failed to respond to M. leprae and most displayed good responses to concanavalin A. Mid-borderline patients (BB) showed intermediate levels of gamma-IFN release. gamma-IFN release by lepromatous patients could be partially restored with purified interleukin 2 and M. leprae antigen but not with interleukin 2 alone.(AU). Descriptors: HANSENIASE/imunol INTERFERON TIPO II/bios MYCOBACTERIUM LEPRAE/imunol ANTIGENOS DE BACTERIAS/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01387/s

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Id: 13416 Author: Bjune, G Title: In vitro lymphocyte stimulation in leprosy; simultaneous stimulation with Mycobacterium leprae antigens and phytohaemagglutinin ..- Source: s.l; s.n; jun. 1979. 9 p. tab, graf. Abstract: Peripheral blood lymphocytes from 105 subjects with different forms of leprosy and healthy contacts of leprosy patients weere stimulated in vitro different preparations of mycobacterial antugens alone or in combination with a suboptimal dose of phytohaemagglutinin (PHA). In nearly all individuals sonicated leprosy bacilli and PHA together gave a lower 3H-thymidine incorporation than didi the same dose of PHA alone. There was no difference in the degree of inhibition seen in the different patient groups or the healthy contacts. High doses of whole, washed Mycobacterium leprae, combined with PHA led to an increased thymidine incorporation in borderline tuberculoid leprosy patients who had experienced a reversal reaction, and in healthy contacts with less than 6 months exposure did not show an augmentation of the PHA-induced thymidine incorporation. The inhibition exerted by sonicated M. leprae was dose-dependent, seen even with very low doses of antigen, and was not due to direct Cytotoxicity, M. bovis, strain BCG, was weakly suppressive effect. There was no correlation between the suppressive effective of M. leprae antigens and the other mtcobacteria neither was there any correlation with the responses to the mycobacterial antigens alone. Many lepromatous leprosy patients showed significant suppression of background incorporation with addition of M. leprae antigens. This paper discusses wheter the apparent `non-responsiveness` in lepromatous leprosy could be due to active suppressor mechanisms operative in vitro.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol HANSENIASE/imunol HANSENIASE/metab TRANSFORMACAO LINFOCITICA TIMIDINA/metab FITOHEMAGLUTININAS/farmacol MYCOBACTERIUM LEPRAE/imunol RELACAO DOSE-RESPOSTA IMUNOLOGICA LINFOCITOS/metab Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00020/s

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Id: 13283 Author: Bahr, G. M; Rook, G. A. W; Stanford, J. L Title: Prostaglandin-dependent regulation of the in vitro paroliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy ..- Source: s.l; s.n; sep. 1981. 8 p. tab, graf. Abstract: The response to soluble mycobacterial antigens of peripheral blood mononuclear cells, from most normal donors, tuberculosis patients or cases of tuberculoid leprosy (TT/BT) was enhanced by the addition of indomethacin. In contrast, indomethacin caused no enhancement of the response of cells from lepromatous leprosy (BL/LL) cases. Moreover the addition of 10-5M prostaglandin E2 (PGE2) failed to inhibit the proliferative responses of cells from the BL/LL patients, although it markedly inhibited the responses of peripheral blood mononuclear cells from the other groups. The addition of PGE2 or indomethacin to cells which had been precultured for 48 hours had no significant effect on the proliferative responses of cells from any of the groups of donors. These results suggest that a normal, prostaglandin-dependent, indomethacin-sensitive regulatory mechanism is absent from the peripheral blood mononuclear cells of BL/LL patients.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE FUNGOS/imunol CANDIDA ALBICANS/imunol DIVISAO CELULAR/ef drogas DINOPROSTONA RELACAO DOSE-RESPOSTA A DROGA INDOMETACINA/farmacol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA/ef drogas MYCOBACTERIUM/imunol - LINFOCITOS/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00540/s

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Id: 13282 Author: Hirschberg, H Title: The role of macrophages in the lymphoproliferative response to mycobacterium leprae in vitro ..- Source: s.l; s.n; oct. 1978. 6 p. tab. Abstract: Peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro stimulation by Mycobacterium leprae antigens. In contrast, we found that T cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to M. leprae. Conversely, T cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. I seems, therefore, that the lack of response normally observed in in vitro tests using cells from lepromatous leprosy patients is due to a failure of their macrophages to present M. leprae antigens is an immunogenic form.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA COOPERACAO LINFOCITICA MACROFAGOS/imunol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T/imunol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00541

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Id: 13281 Author: Smelt, A. H. M; Rees, R. J. W; Liew, F. Y Title: Failure to induce delayed-type hipersensivity to Mycobacterium leprae in long-term treated lepromatous leprosy patients ..- Source: s.l; s.n; jun. 1981. 5 p. tab, graf. Abstract: Lepromatous leprosy (LL) patients whose bacillary load has decreased to almost undetectable levels by long-term chemotherapy failed to develop delayed-type hypersensitivity (DTH) to Mycobacterium leprae antigen following immunization with killed armadillo-derived m. leprae. When these LL patients were immunized with killed M. leprae in a mixture with live BCG, only DTH to purified protein derivative (PPD) was induced. These results are further evidence that immunological unresponsiveness to the leprosy antigen of patients with lepromatous leprosy is antigen-specific and non-reversible.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol HIPERSENSIBILIDADE TARDIA IMUNIZACAO HANSENIASE/quimioter HANSENIASE/imunol MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol TESTES CUTÂNEOS Limits: SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00542/s

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Id: 13280 Author: Nath, Indira; Van Rood, J. J; Mehra, N. K; Vaidya, M. C Title: Natural supressor cells in human leprosy: the role of HDLA-D-identical peipheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses ..- Source: s.l; s.n; nov. 1980. 8 p. tab. Abstract: Six families with HLA-D-identical siblings suffering from leprosy were studied. Lymphocytes and macrophages isolated from the peripheral blood were co-cultured with allogeneic, HLA-D-identical cells and stimulated with M. Leprae antigens and concanavalin A. tuberculoid patients had circulating lymphocytes which showed marked functional suppression of lymphoproliferative responses to antigen and mitogen. In contrast, lepromatous patients showed weak lymphocyte suppressor activity. Macrophages derived from responder individuals augmented, while those derived from lepromatous patients inhibited, M. leprae-induced proliferation of lymphocytes.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol CONCANAVALINA A/farmacol ANTIGENOS DE HISTOCOMPATIBILIDADE CLASSE II IMUNIDADE CELULAR HANSENIASE/genet HANSENIASE/imunol TRANSFORMACAO LINFOCITICA MACROFAGOS/imunol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00544/s

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Id: 13232 Author: Girdhar, B. K; Desikan, K. V Title: Results of skin tests with five different mycobacteria ..- Source: s.l; s.n; oct. 1978. 5 p. ilus, tab. Abstract: A comparison of intradermal response to injection of Dharmendra type of coded antigens, prepared from different species of Mycobacteria by Prof. G.P. Talwar has been made over 3 weeks period. The results are reported.(AU). Descriptors: ESTUDOS DE AVALIACAO HANSENIASE/imunol HANSENIASE/microbiol MYCOBACTERIUM/imunol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM PHLEI/imunol ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE BACTERIAS/imunol TESTES INTRADERMICOS Limits: ESTUDO COMPARATIVO HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 02119/s

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Id: 13231 Author: Mustafa, A. S; Talwar, G. P Title: Delayed hypersensitivity skin reactions to homologous and heterologous antigens in guinea-pigs immunized with M. leprae and four selected cultivable mycobacterial strains ..- Source: s.l; s.n; oct. 1978. 11 p. tab. Abstract: Guinea-pigs were immunized with Mycobacterium leprae in saline and with autoclaved preparations of Mycobacterium w., ICRC bacillus, Mycobacterium phlei and Mycobacterium vaccae. A group of animals were also immunized with live Mycobacterium w. All animals were challenged after one month of M. leprae and other mycobacteria. Induration produced in response in guine-pigs to challenge with homologous mycobacterial preparations and M. leprae. In most cases, the early reaction was higher with homologous antigens as compared to M. leprae antigens were however of comparable order especially in animals immunized with Mycobacterium w, and ICRC bacillus. Animals immunized with M. leprae gave low late reactions with preparations from Mycobacterium phlei and Mycobacterium vaccae.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS HETEROFILOS/imunol HIPERSENSIBILIDADE TARDIA/etiol TESTES INTRADERMICOS MYCOBACTERIUM/imunol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM PHLEI/imunol IMUNIZACAO Limits: ESTUDO COMPARATIVO HUMANO ANIMAL COBAIAS Electronic Medium: http://www.ilsl.br Location: BR191.1; 02120/s

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Id: 13212 Author: Govil, D. C; Bhutani, L. K Title: Delayed hypersensitivity skin reactions to lepromin and antigens prepared from four other mycobacteria ..- Source: s.l; s.n; oct. 1978. 5 p. tab. Abstract: Antigens prepared from five mycobacteria viz. M. leprae M. vaccae, M. phlei, M.W and ICRC bacillus were used for assessing cross reactivity between different antigens on sixteen patients with different forms of leprosy. ICRC bacillus and M.W gave the best correlation with M. leprae.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol HIPERSENSIBILIDADE TARDIA/diag ANTIGENO DE MITSUDA/imunol HANSENIASE/imunol HANSENIASE/microbiol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM/imunol MYCOBACTERIUM PHLEI/imunol Limits: ESTUDO COMPARATIVO HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 02116/s

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Id: 13211 Author: Sharma, R. C; Singh, R Title: Comparative study of skin reactions in leprosy patients to M. leprae-lepromin and to antigens from cultivable saprophytic mycobacteria ..- Source: s.l; s.n; oct. 1978. 7 p. tab. Abstract: 18 cases of different types of leprosy were studied to see the skin reactions to known lepromin and to antigens from four cultivable saprophytic mycobacteria. ICRC bacillus gave best results in tuberculoid leprosy - even as campared to M. leprae, whereas M. delhi (M.W.) with M. leprae is concerned, there was hardly any difference between the two.(AU). Descriptors: HANSENIASE/imunol MYCOBACTERIUM/imunol MICOBACTERIOSE/imunol ANTIGENO DE MITSUDA/imunol ANTIGENOS DE BACTERIAS/imunol MICOBACTERIOSE ATIPICA/imunol MYCOBACTERIUM LEPRAE/imunol Limits: ESTUDO COMPARATIVO HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 02117/s

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Id: 13197 Author: Stanford, J. L Title: Skin testing with mycobacterial reagents in leprosy ..- Source: s.l; s.n; mar. 1984. 12 p. tab, graf. Abstract: Skinh test reagents that have been used to investigate the disease process, immunology and epidemiology of leporsy include preparations of leprosy bacilli themselves, of Mycobacterium tuberculosis and of a range of other mycobacterial species.(AU). Descriptors: HANSENIASE/diag HANSENIASE/imunol ANTIGENO DE MITSUDA/imunol MYCOBACTERIUM/imunol MYCOBACTERIUM LEPRAE/imunol TESTES CUTÂNEOS/métodos TOLERÂNCIA IMUNOLOGICA IMUNOSSUPRESSAO ANTIGENOS DE BACTERIAS/imunol TUBERCULINA/imunol EPITOPOS/anal Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 02109/s

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